http://spectroscopymag.findpharma.com/spectroscopy Spectroscopy Magazine Online provides practical advice about modern spectroscopic techniques and instrumentation to solve real-world problems in diverse physical and life science disciplines. 2008-09-07T21:20:18Z http://spectroscopymag.findpharma.com/spectroscopy/News/Spectroscopy-Shows-Brain-Dysfunction-in-Patients-w/ArticleStandard/Article/detail/546381?ref=25 Researchers used proton magnetic resonance spectroscopy to highlight the differences in the levels and ratios of certain brain chemicals in the hippocampus of patients with fibromyalgia syndrome compared with a control group of healthy women. 2008-08-29T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/EDAX-Introduces-New-Series-of-Lab-Solutions/ArticleStandard/Article/detail/545381?ref=25 EDAX, Inc. (Mahwah, New Jersey) has recently introduced several new items that reportedly will enhance productivity and efficiency in the spectroscopy laboratory. 2008-08-28T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Thermo-Fisher-Scientific-to-Host-Seminar/ArticleStandard/Article/detail/545144?ref=25 Thermo Fisher Scientific has announced that it will exhibit and host a seminar at the annual Pharmatex conference at the Radisson SAS Hotel, Cork, Ireland, 16-18 September. 2008-08-27T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/ASD-Inc-Named-to-Inc-5000-List-for-Second-Consecut/ArticleStandard/Article/detail/544869?ref=25 Inc. Magazine has named ASD to their Inc. 5000 list for the second consecutive year. 2008-08-26T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Evidence-for-Embalming-in-Roman-Greece/ArticleStandard/Article/detail/544951?ref=25 Using electron microscopy and gas chromatography-mass spectrometry, researchers found evidence of embalming in Roman Greek times. 2008-08-26T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Uncovering-Art-History-Through-Spectroscopy/ArticleStandard/Article/detail/544899?ref=25 Researchers at Delft University of Technology (The Netherlands) and the University of Antwerp (Antwerp, Belgium) used synchrotron radiation-induced X-ray fluorescence spectroscopy to reveal a portrait of a woman by Vincent van Gogh beneath the paint of his 1887 "Patch of Grass." 2008-08-25T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-UV-vis/ArticleStandard/Article/detail/542024?ref=25 This month's Technology Forum looks at the topic of UV-vis and the trends and issues surrounding them. Joining us for this discussion are Rob Morris, from Ocean Optics; Richard A. Larsen, Ph.D., from Jasco; and John Monti, from Shimadzu. 2008-08-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-X-ray-Spectroscopy/ArticleStandard/Article/detail/531878?ref=25 This month's Technology Forum looks at the topic of X-ray Spectroscopy and the trends and issues surrounding them. Joining us for this discussion are Dr Simon FitzGerald, from HORIBA Jobin Yvon, Dr. Kai Behrens, from Bruker AXS, Inc., and Peter LaPuma and Alexander Seyfarth, also from Bruker AXS, Inc. 2008-07-25T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/LCGC-to-Host-PharmSep-Symposium/ArticleStandard/Article/detail/528289?ref=25 LCGC North America, the leading information provider and most trusted source among chromatographers, has announced PharmSep, a Premiere Symposium for Separation Scientists in Pharmaceuticals. 2008-07-08T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/The-Use-of-Liquid-Chromatography-with-Tandem-Mass-/ArticleStandard/Article/detail/528045?ref=25 Liquid chromatography with tandem mass spectrometry (LC–MS-MS) led to a revolution in environmental testing. The coupling of liquid chromatography with tandem mass spectrometry created a powerful analytical tool for the analysis of emerging environmental contaminants. Pharmaceuticals and personal care products, perfluorinated compounds, brominated flame retardants, and disinfection byproducts were chosen as examples to illustrate the use of this new technique in environmental analysis. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry+Forum+Column/Quantitative-Mass-Spectrometry-Part-IV-Deviations-/ArticleStandard/Article/detail/528885?ref=25 In the fourth part of a five-part series, columnist Ken Busch discusses factors that might cause deviation from linearity at the upper and lower limits of a calibration curve. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+News+Spectrum+Column/News-Spectrum/ArticleStandard/Article/detail/528883?ref=25 Thermo Fisher Scientific, Inc. (Waltham, MA) announces the launch of its comprehensive online resource center, www.thermo.com/metabolomics, for metabolomics researchers. This website provides tools and technical advice to help scientists studying small-molecule metabolite profiles. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Calendar/Calendar/ArticleStandard/Article/detail/528891?ref=25 Calendar 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/Dosing-Vehicle-Removal-in-Discovery-Phase-Pharmaco/ArticleStandard/Article/detail/528041?ref=25 This article describes the ability to increase the sensitivity for a target compound in the presence of high-level background impurities by removing the dosing vehicle using a high-field asymmetric waveform ion mobility spectrometry gas-phase separation before mass spectrometry analysis. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/Determination-of-Volatile-Organic-Compounds-in-Wat/ArticleStandard/Article/detail/528046?ref=25 Over the last 10 years, several solvent-free microextraction techniques for gas chromatography (GC) and mass spectrometry (MS) have been developed. Two of these techniques, solid-phase microextraction (SPME) and stir-bar sorptive extraction (SBSE), are available commercially for the analysis of volatile compounds, such as flavors in foods and beverages, and toxic organic compounds in environmental applications. Other techniques, such as open tubular trapping, inside needle capillary adsorption trap (1), in-tube SPME, capillary microextraction, needle trap, and headspace solid-phase dynamic extraction (2), were also developed for different applications. The basic principle for all of these techniques is essentially the same. Volatile and semivolatile compounds are adsorbed on a sorbent coating, often packed on the interior surface of a capillary column or stainless steel needle. After the sample is concentrated on the coating, the compounds are desorbed thermally in the heated injection port of a gas.. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Conferences+and+Exhibitions/DXC-2008-The-Worlds-Leading-Forum-for-X-Ray-Materi/ArticleStandard/Article/detail/528888?ref=25 A preview of the 57th Annual Denver X-Ray Conference, to be held August 4–8 in Denver, Colorado. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/Synthesis-and-Structural-Elucidation-of-Impurities/ArticleStandard/Article/detail/528044?ref=25 Ramipril impurities D and E are well-known degradation products of ramipril in the finished dosage form. A significant amount of an additional impurity was detected in ramipril tablets by an isocratic reversed-phase high performance liquid chromatography (HPLC) method on a short column. The structure of this impurity was proposed based on liquid chromatography–mass spectrometry (LC–MS) data using an electron spray ionization source. Structural elucidation using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy was facilitated by a newly developed preparative isolation method. This impurity was characterized as (2R,3aR,6aR)-1-[(R)-2-[[(R)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (impurity L). Its identification, synthesis and characterization are discussed. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Market+Profile+Column/Market-Profile-Cement-Analysis-by-XRF/ArticleStandard/Article/detail/528884?ref=25 X-ray fluorescence spectroscopy (XRF) is one of the primary analytical tools used in the cement industry for a variety of related applications. The principle of XRF is relatively simple; a source directs X-rays onto the atoms of the sample, ejecting electrons from the inner electron shells. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/Gas-ChromatographyndashTime-of-Flight-Mass-Spectro/ArticleStandard/Article/detail/528040?ref=25 Illegal drug use worldwide is at an all-time high. There is a crucial need for fast and accurate analysis to positively identify suspected drugs in criminal investigations. Gas chromatography combined with time-of-flight mass spectrometry (GC–TOFMS) can be a valuable tool for drug testing in forensic crime laboratories. Method development and GC–TOFMS experimentation was conducted in cooperation with a local crime laboratory. The laboratory testing presented will illustrate highly efficient methods and data developed for crime labs that assist in the battle against illegal drugs. Many drug classes have chemical properties that present particular analytical challenges, such as poor detector response, chemical lability, or poor chromatographic peak shape. This article presents GC–TOFMS methods developed for several major drug classes and chemical functionalities. The major drugs included in the initial method development are methamphetamine, ecstasy, and heroin. Robust and accurate.. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Conferences+and+Exhibitions/The-56th-Annual-ASMS-Conference-A-Review/ArticleStandard/Article/detail/528047?ref=25 A summary of the five-day mass spectrometry conference held this month in Denver, Colorado. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/Surface-Enhanced-Raman-Spectroscopy-A-New-Approach/ArticleStandard/Article/detail/528889?ref=25 Surface-enhanced Raman spectroscopy (SERS) has experienced an explosive resurgence in interest lately. Development of reproducible, spatially uniform SERS-active substrates has made this technique an attractive approach for identification of Raman-active compounds and biological materials including toxins, intact viruses, and intact bacterial cells–spores... 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Products/ArticleStandard/Article/detail/528890?ref=25 Hitachi introduces two new versions of the U-4100 UV-Vis-NIR Spectrophotometer: the Standard Solid Sample System and Large Solid Sample System. These new systems use PMT and InGaAs detectors, providing increased sensitivity in the range of 850–1700 nm. This results in reduced noise, making the instrument suitable for the measurement of low transmitting/reflecting anti-reflection coatings. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/A-Simplified-Approach-to-Optimize-SPE-Method-Devel/ArticleStandard/Article/detail/528042?ref=25 Automated solid-phase extraction (SPE) has been used extensively with liquid chromatography–tandem mass spectrometry (LC–MS-MS) to facilitate high-throughput analysis in the pharmaceutical, diagnostic, and forensic toxicology areas. In this work, we demonstrate the use of a systemized approach to SPE method development and LC–MS-MS analysis. This approach provides dramatic savings in analysis time and takes advantage of new innovations in high performance liquid chromatography (HPLC) columns to provide the cleanest extracts for LC–MS injection. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Product-Resources/ArticleStandard/Article/detail/528048?ref=25 Product Resources 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Focus+on+Quality+Column/Validation-of-Spectrometry-Software-Understanding-/ArticleStandard/Article/detail/528886?ref=25 Columnist Bob McDowall discusses the role of a validation master plan (VMP) for summarizing a laboratory's approach to computer validation. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Atomic+Perspectives+Column/Wilhelm-Conrad-Roumlntgen-and-the-Discovery-of-X-R/ArticleStandard/Article/detail/528887?ref=25 Volker Thomsen takes a look at the impact that the discovery of X-rays by Wilhelm Röntgen in 1895 has had on the world. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry/Posttranslational-Modification-Characterization-vi/ArticleStandard/Article/detail/528043?ref=25 Successful characterization of protein posttranslational modifications (PTMs) is critical to our understanding of many biological processes. Unfortunately, attempts to describe PTMs often prove experimentally difficult and result in ambiguous conclusions. As technologies in the field of mass spectrometry (MS) continue to improve, people are turning increasingly to mass spectral techniques for PTM characterization. Recently, novel modes of peptide fragmentation have emerged that are giving scientists greater ability to elucidate protein posttranslational modification. One example is electron-capture dissociation (ECD), an alternative fragmentation mechanism for use in peptide analysis via tandem mass spectrometry. ECD selectively cleaves N-Cα bonds of the peptide backbone, yielding c- and z-ions without the loss of labile PTMs. ECD therefore holds advantages over conventional fragmentation techniques such as collisionally induced dissociation (CID), which often cleave PTMs from the peptide backbone,.. 2008-07-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Highlights-of-the-56th-Annual-ASMS-Conference-on-M/ArticleStandard/Article/detail/524216?ref=25 Spectroscopy Magazine was well represented at the 56th Annual ASMS Conference on Mass Spectrometry, held at the Colorado Convention Center in Denver, Colorado, from June 1?5, 2008. 2008-06-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-Raman/ArticleStandard/Article/detail/523752?ref=25 This month's Technology Forum looks at the topic of Raman and the trends and issues surrounding it. Joining us for this discussion are Dr. Troy Alexander, Teamleader of the Radiometric Sensor Development and Applications Team at the U. S. Army Research Laboratory-Sensors and Electron Devices Directorate; Joe Hodkiewicz, Director of Raman, with Thermo Fisher Scientific; and Dr. Jorge Macho, Director, Total Technical Service, with Ocean Optics, Inc. 2008-06-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Featured-Products/ArticleStandard/Article/detail/524275?ref=25 Featured products from the spectroscopy industry. 2008-06-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Question-of-the-Month-Raman/ArticleStandard/Article/detail/524214?ref=25 What new development in the Raman field has you most excited? 2008-06-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Fiberguide-Industries-Recognized-by-Lawrence-Liver/ArticleStandard/Article/detail/522561?ref=25 Fiberguide Industries, Inc. has been formally recognized by Lawrence Livermore National Laboratory, Livermore, California, for their participation and contributions in the National Ignition Facility (NIF) program 2008-06-09T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/Advantages-and-Limitations-of-Modular-Fiber-Optics/ArticleStandard/Article/detail/529181?ref=25 Raman spectroscopy is going through a major revolution with the continuous introduction of new fiber-based modular systems for low-resolution applications. More and more scientists are discovering what Raman spectroscopy can do for their research, education, and commercial applications thanks to the low costs and flexibility this new technology is providing. New applications and prospects are presented each day, and it is important to understand the advantages and limitations that this user-friendly analytical technique can provide to address these opportunities with a scientific approach. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Near-IR+Spectroscopy/Miniature-Optical-Spectrometers-The-Art-of-the-Pos/ArticleStandard/Article/detail/525678?ref=25 Part II of this series described many of the miniature optical technologies that were developed as a result of the telecommunications boom, and Part III covered conventional small near-infrared (NIR) spectrometers. Here, in Part IV, we bring those themes together and see how the massive investment in telecommunications, microelectro- mechanical systems (MEMS), and micro-opto-electro-mechanical (MOEMS) is starting to impact NIR spectroscopy. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/A-New-Forensic-Tool-for-Chemical-Identification-Ra/ArticleStandard/Article/detail/529178?ref=25 Chemical analysis in the forensic field is different in many aspects from other areas of analysis. The ultimate goal is to identify the sources of evidence, often by matching chemical composition. In this regard, identifying minor elements or trace impurities is as important as identifying main ingredients. In some cases, identifying minor and trace components can be critical to determining that material collected at the site of a crime is identical to material collected in a suspect's environment. In other cases, full identification of trace evidence can be important. Raman microscopy is capable of providing both types of information on minute amounts of material. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/SERS-Comes-of-Age-for-Molecular-Detection/ArticleStandard/Article/detail/529183?ref=25 Since it was first described in 1974, surface-enhanced Raman spectrometry (SERS) has been thought to offer significant potential for a range of different applications. The theoretical sensitivity and specificity envisaged for this powerful technique has engaged scientists for many years, but practical challenges have hindered its routine adoption. Now, a new approach combines a robust and reliable substrate with expertise in surface chemistry and molecular biology on a platform that can be adapted for a wide variety of Raman instrumentation and customized routine applications. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Market+Profile+Column/Market-Profile-Portable-and-Handheld-Raman/ArticleStandard/Article/detail/525675?ref=25 The continuing pace of technological advancements in scientific instruments has recently led to a wide range of commercially viable portable and handheld instruments, and the Raman spectroscopy market is no exception. While security applications have received much of the early attention in relation to handheld instruments, other applications are beginning to replace demand from the security markets. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Chemometrics+in+Spectroscopy+Column/The-Long-Complicated-Tedious-and-Difficult-Route-t/ArticleStandard/Article/detail/525677?ref=25 Howard Mark and Jerome Workman, Jr. continue their discussion of the derivation of the principal component algorithm using elementary algebra. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Infrared+Spectroscopy/IR-Spectroscopy-Analysis-of-Disposable-Gloves-for-/ArticleStandard/Article/detail/525679?ref=25 Residue can be transferred from gloves to samples at detectable levels, especially in attenuated total reflectance infrared spectra. Some residues can be removed easily by washing and drying the gloves in a manner similar to washing and drying hands. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/From-Tablets-to-Teeth-Complete-Raman-Imaging/ArticleStandard/Article/detail/529182?ref=25 Raman imaging has moved on. It is now possible to capitalize on the wealth of information available from a Raman spectrum by imaging materials over large areas, with the spatial resolution, spectral resolution, and laser excitation parameters tailored to suit each application. Raman experiments and images from a diverse range of samples are presented. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/The+Baseline+Column/Spectroscopy-Is-Applied-Quantum-Mechanics-Part-IV-/ArticleStandard/Article/detail/525676?ref=25 In Parts I-III of this series, columnist David W. Ball recounted the failings of classical mechanics, the quantum hypothesis, and the rise of a new theory called quantum mechanics. In this installment, he discusses the ideal systems whose wavefunctions can be determined exactly from the Schr?dinger equation. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/The-Importance-of-Rigorous-Instrument-Calibration-/ArticleStandard/Article/detail/529180?ref=25 Over the last few years, Raman has made the transition from a technique used solely in a research environment to one that is now seen as a powerful tool for routine analytical use. Raman spectroscopy now is used widely for sample identification in fields as diverse as forensics, QA/QC, art conservation, defect analysis, and failure analysis. This has imposed new demands on the technique for reproducibility and stability. Successful sample identification takes advantage of the extensive spectral libraries and sophisticated search algorithms that have been developed in recent years. However, in order to be able to cross-correlate experimental and library spectra with any degree of confidence, it is critical that the Raman spectrometers used to collect the spectra are calibrated rigorously. It is likewise critical for QC applications that spectra collected on one instrument can be compared reliably with spectra collected on other instruments and that results remain constant when collected over extended periods.. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Spectroscopy-2008-e-Media-Kit-v2/ArticleStandard/Article/detail/520773?ref=25 Spectroscopy 2008 e-Media Kit v2 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Calendar/Calendar/ArticleStandard/Article/detail/525680?ref=25 Upcoming events in the spectroscopy field. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+News+Spectrum+Column/News-Spectrum/ArticleStandard/Article/detail/525674?ref=25 News items from the spectroscopy industry. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Products/ArticleStandard/Article/detail/525681?ref=25 Featured products from the spectroscopy marketplace. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Raman+Spectroscopy/Automated-Confocal-Raman-and-Atomic-Force-Microsco/ArticleStandard/Article/detail/529179?ref=25 The combination of confocal Raman and atomic force microscopes allows chemical and surface topography imaging of large samples without any ongoing process control by an operator. This article describes the relevant measurement principles and presents examples of automated measurements on nanostructured materials. 2008-06-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Applications-are-now-being-accepted-for-the-2009-G/ArticleStandard/Article/detail/519365?ref=25 Applications are now being accepted for the 2009 Gordon Kirkbright Bursary. 2008-05-28T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/The-American-Institute-of-Chemists-Philadelphia-PA/ArticleStandard/Article/detail/519366?ref=25 The American Institute of Chemists (Philadelphia, PA) has announced the recipients of the 2008 AIC Gold Medal. 2008-05-28T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/News/Thermo-Fisher-Scientific-Inc-has-established-a-new/ArticleStandard/Article/detail/519360?ref=25 Thermo Fisher Scientific Inc. has established a new partnership with Alta Tecnologia to extend its informatics offerings in Chile. 2008-05-28T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Featured-Products/ArticleStandard/Article/detail/516677?ref=25 Featured products from the spectroscopy industry. 2008-05-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-May-2008/ArticleStandard/Article/detail/516683?ref=25 This month's Wavelength includes the Wavelength Tech Forum on mass spectrometry, the Question of the Month, and featured products from the spectroscopy industry. 2008-05-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-Mass-Spectrometry/ArticleStandard/Article/detail/516681?ref=25 This month's Technology Forum looks at the topic of mass spectrometry and the trends and issues surrounding it. Joining us for this discussion are Gary Impey, Senior Manager in Applied Biosystems' Proteomics and Small Molecule Division, and Dominic Gostick, Director of Product Marketing for Biomarkers and Proteomics at Applied Biosystems. 2008-05-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Question-of-the-Month-Mass-Spectrometry/ArticleStandard/Article/detail/516680?ref=25 What new developments on the mass spectrometry horizon have intrigued you? 2008-05-13T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Products/ArticleStandard/Article/detail/515902?ref=25 Featured products from the spectroscopy marketplace. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/What-Is-in-Your-Water/ArticleStandard/Article/detail/515917?ref=25 Specific purity requirements are set for water sources, whether we deal with waste, ground, surface, or drinking water. Water quality is key, and it is becoming a focal point for an increasing number of communities worldwide. Water quality determines the use of a body of water such as for manufacturing, farming, fishing, and human consumption. The reason to strive to maintain or improve a given body of water is to preserve or upgrade its quality, because once this quality degrades, so does its value. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/Use-of-Electron-Capture-Negative-Ion-Mass-Spectra-/ArticleStandard/Article/detail/515916?ref=25 Detrimental health effects of a group of brominated flame retardants, polybrominated diphenyl ethers (PBDEs), have been recognized recently, but only after their wide usage and consequently, global dispersal. Of the possible 209 PBDE congeners, 39 (varying in degree of bromination from mono to deca) have been identified previously in the three common technical mixtures. Additional congeners, presumably debromination products of the fully brominated decabromodiphenyl ether (BDE-209), also have been reported in biotic and abiotic environments. However, costly analytical standards are needed to confirm their identification. In addition, the most widely used identification approach, electron ionization (EI) mass spectrometry (MS), primarily produces spectra indicating only homologue grouping (for example, hepta-BDE). Without specific compound identification, full assessment of toxicological consequences of PBDE burdens is impeded. It has been reported previously that electron-capture negative ionization (ECNI),.. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Product-Resources/ArticleStandard/Article/detail/515922?ref=25 Featured products from the spectroscopy marketplace. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Chemometrics+in+Spectroscopy+Column/The-Long-Complicated-Tedious-and-Difficult-Route-t/ArticleStandard/Article/detail/515898?ref=25 Howard Mark and Jerome Workman, Jr. continue their discussion of the derivation of the principal component algorithm using elementary algebra. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Atomic+Perspectives+Column/A-Pragmatic-Approach-to-Managing-Interferences-in-/ArticleStandard/Article/detail/515899?ref=25 While inductively coupled plasma-mass spectrometry (ICP-MS) is capable of part-per-quadrillion (ppq) detection limits under ideal conditions, most applications do not require this level of sensitivity and do not justify the cost associated with achieving it. Practical sensitivity in ICP-MS is determined not by instrument signal-to-noise ratio, but rather by controlling interferences and matrix effects in real samples. Understanding the sources of these effects and their management is critical in determining the most practical way to achieve specific data quality objectives. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/Metabolite-Identification-Using-Multiple-Mass-Defe/ArticleStandard/Article/detail/515918?ref=25 In this article, the authors evaluate the use of multiple mass defect filters on metabolite identification data from a hybrid mass spectrometer. The study also investigates the use of higher energy collisional dissociation for structural elucidation in metabolite identification experiments. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Calendar/Calendar/ArticleStandard/Article/detail/515903?ref=25 Upcoming events in the spectroscopy field. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Conferences+and+Exhibitions/Pittcon-2008-Back-to-New-Orleans-and-Coffee-and-Be/ArticleStandard/Article/detail/515900?ref=25 John Coates presents a comprehensive review of the products and accessories introduced at Pittcon this year. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Market+Profile+Column/Market-Profile-MALDI-Imaging/ArticleStandard/Article/detail/515897?ref=25 The adoption of MALDI-TOF mass spectrometry for imaging applications is a major recent development in the market. Applications lie squarely in the life sciences area, being primarily in histopathology. The market for MALDI imaging products already accounts for a significant and rapidly growing portion of the aftermarket for MALDI-TOF mass spectrometry. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+News+Spectrum+Column/News-Spectrum/ArticleStandard/Article/detail/515896?ref=25 News items from the spectroscopy industry. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/GSH-Conjugate-Metabolite-Identification-with-a-Hyb/ArticleStandard/Article/detail/515921?ref=25 In drug discovery, determining information about the extent of metabolism and the elucidation of metabolite structures is a vital step for lead optimization and drug scaffold refinement. The identification and characterization of metabolites plays an important role in both the drug discovery and development phases, as unsuitable pharmacokinetics (bioavailability and drug distribution), toxicity, and adverse drug reactions might be linked to metabolic instability. Historically, metabolite identification was carried out after a compound had been chosen for drug development. However, to reduce candidate failures attributed to toxicity effects, many pharmaceutical companies now conduct these experiments in the earliest phases of candidate drug selection. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/Calibration-Stability-for-Formula-Determination-on/ArticleStandard/Article/detail/515919?ref=25 With electron ionization (EI) used in most gas chromatography–mass spectrometry (GC–MS) applications, the molecular ion typically is broken apart into multiple fragment ions during the EI process. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Near-IR+Spectroscopy/Miniature-Optical-Spectrometers-Part-III-Conventio/ArticleStandard/Article/detail/515901?ref=25 In Part I of this series, we examined recently developed miniature mid-infrared spectrometers (1). In Part II, we surveyed micro electro mechanical systems (MEMS), micro-opto-electro-mechanical systems (MOEMS), and some of the photonics technologies developed for optical communications (2). Here, in Part III, we summarize some of the conventional approaches to miniaturizing near-infrared (NIR) spectrometers, and in Part IV, we will bring these themes together and see how MOEMS and telecommunications photonics are poised to revolutionize NIR spectroscopy with a new generation of miniature instruments. 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/A-Comparison-of-ICP-OES-and-ICP-MS-for-the-Determi/ArticleStandard/Article/detail/515920?ref=25 The determination of inorganic elements in food substances is critical for assessing nutritional composition and identifying food contamination sources. The inorganic elements of interest can be divided into two classes: nutritional and toxic. It is important to determine the levels of both sets of elements accurately to assess both the nutritional and the harmful impacts of food substances. Nutritional elements such as Mg, P, and Fe are present at high levels (milligrams per kilogram), while toxic elements such as Pb, Hg, and Cd should be present only at trace levels (nanograms or micrograms per kilogram). 2008-05-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-April-2008/ArticleStandard/Article/detail/510164?ref=25 This month's Wavelength includes the Wavelength Tech Forum on Optics/Lasers, the Question of the Month, and featured products from the spectroscopy industry. 2008-04-15T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Question-of-the-Month-OpticsLasers/ArticleStandard/Article/detail/510159?ref=25 What has been the single-most important development in the field of optics in recent years? 2008-04-15T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-OpticsLasers/ArticleStandard/Article/detail/510162?ref=25 This month's Technology Forum looks at the topic of Optics/Lasers and the trends and issues surrounding them. Joining us for this discussion are Eric Bergles, with BaySpec, and Rob Morris, with Ocean Optics. 2008-04-15T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Featured-Products/ArticleStandard/Article/detail/510151?ref=25 Featured products from the spectroscopy industry. 2008-04-15T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Market+Profile+Column/Market-Profile-MALDI-Tandem-Mass-Spectrometry/ArticleStandard/Article/detail/507427?ref=25 First developed in the mid-1980s, matrix assisted laser desorption ionization (MALDI) added a complementary mass spectrometry ionization technique to others that were already on the market, such as electrospray ionization (ESI). 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Atomic+Perspectives+Column/Innovations-in-Speciation-Analysis-Using-HPLC-with/ArticleStandard/Article/detail/507430?ref=25 Speciation analysis has grown rapidly and has expanded to a variety of markets, including environmental, clinical, food, nutraceutical, and bioanalytical. This growth has resulted from the realization that knowing the total amount of an element does not always provide adequate information for assessing health and environmental effects, but knowing which form of the element is present presents a much more comprehensive picture. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/The+Baseline+Column/Spectroscopy-Is-Applied-Quantum-Mechanics-Part-III/ArticleStandard/Article/detail/507428?ref=25 Columnist David W. Ball discusses the pioneering work of Erwin Schrodinger, whose work on wave mechanics forms the basis of the modern understanding of subatomic behavior. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Focus+on+Quality+Column/Understanding-the-Implications-of-the-2008-GMP-Upd/ArticleStandard/Article/detail/507429?ref=25 U.S. Good Manufacturing Practice (GMP) regulations (21 CFR 211) have existed unchanged since 1978 (1), although in 1996 a draft amendment was issued but was never implemented (2). However, on December 4, 2007, the FDA issued a Direct Final Rule for 21 CFR 211 that will make changes to GMP for finished pharmaceuticals (3) effective in April 2008 as well as withdrawing the draft 1996 amendment (4). This is the first phase in changes that will be made by the FDA to update and harmonize the GMP regulations over the next few years. In this "Focus on Quality" column, we will look at the overall GMP changes and then ask the following question: Why has the laboratory not been included in the proposed changes? 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/New+Techniques/Single-Particle-Spectroscopy-on-Conducting-Polymer/ArticleStandard/Article/detail/507431?ref=25 The study of the photophysical and optoelectronic properties of a functioning conducting polymer device is complicated and is hampered by the complex nanostructure and morphology of the conducting polymer materials in these devices. Here we discuss an approach to investigate this issue in terms of bulk-heterojunction organic photovoltaic devices. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Products/Products/ArticleStandard/Article/detail/507432?ref=25 Featured products from the spectroscopy marketplace. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+Calendar/Calendar/ArticleStandard/Article/detail/507433?ref=25 Upcoming events in the spectroscopy field. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Departments%3A+News+Spectrum+Column/News-Spectrum/ArticleStandard/Article/detail/507426?ref=25 News items from the spectroscopy industry. 2008-04-01T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Spectroscopy-December-2007-BPA-Statement/ArticleStandard/Article/detail/505844?ref=25 Spectroscopy December 2007 BPA Statement 2008-03-25T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Question-of-the-Month-Pittcon-2008/ArticleStandard/Article/detail/503408?ref=25 What is your preferred Pittcon location? 2008-03-17T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Featured-Products/ArticleStandard/Article/detail/503403?ref=25 Featured products from the spectroscopy industry. 2008-03-17T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-March-2008/ArticleStandard/Article/detail/503414?ref=25 This month's Wavelength includes the Wavelength Tech Forum on Pittcon 2008, the Question of the Month, and featured products from the spectroscopy industry. 2008-03-17T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Wavelength-Tech-Forum-Pittcon-2008/ArticleStandard/Article/detail/503410?ref=25 This month's Technology Forum looks at the topic of Pittcon 2008 and the issues surrounding it. Joining us for this discussion are Jerry Dulude, with Glass Expansion, Kevin McLaughlin, with Shimadzu Scientific Instruments, Ken Kempfert, with PIKE Technologies, and Don Kuehl, with Cerno Bioscience. 2008-03-17T04:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Molecular+Spectroscopy+Workbench+Column/Raman-Applications-That-Are-Driving-a-Rapidly-Expa/ArticleStandard/Article/detail/503645?ref=25 Chemical analysts who use spectroscopy to extract molecular information from samples have been following the developments in Raman instrumentation. Vibrational spectroscopy provides detailed molecular information, but Fourier-transform IR has been much easier to use than Raman. Now that Raman equipment is smaller, cheaper, faster, and easier, analysts are interested. Columnist Fran Adar will discuss why. 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+General/Dangerous-Toys-Rigid-Testing-Routines-Required-to-/ArticleStandard/Article/detail/504363?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/LCndashMS-MS-Determination-of-Malachite-Green-and-/ArticleStandard/Article/detail/505083?ref=25 Although not currently used in U.S. or European aquaculture, malachite green (MG) is still an effective and inexpensive fungicide that is used in other countries, particularly in Asia. During metabolism, MG reduces to leucomalachite green (LMG) (Figure 1), which has been shown to accumulate in fatty fish tissues. Trace levels of MG and LMG residues continue to be found in fish products. In a 2005 report, MG was found in 18 out of 27 live eel or eel products imported from China to Hong Kong local market and food outlets, resulting in a government recall and destruction of all remaining products (1). 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/Trace-Level-Organochlorine-and-Organophosphorus-Pe/ArticleStandard/Article/detail/505086?ref=25 Gas chromatography and comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC–TOFMS and GCxGC–TOFMS) were utilized to develop trace-level calibration curves in brewed green tea spiked with organochlorine and organophosphorus pesticide standards. A sensitive and robust calibration curve was developed from 10 to 500 parts per trillion (ppt), which allowed quantitative results to be determined for organochlorine–organophosphorus pesticides in brewed green tea. Exceptional limits of detection were achieved by GC–TOFMS and GCxGC–TOFMS at or below 10 ppt (solution concentration) for all but one of the pesticides. Stir bar sorption extraction (SBSE) was utilized to isolate the pesticide components from brewed green tea samples prior to analysis by GC–TOFMS and GCxGC–TOFMS. Different types of green tea were analyzed qualitatively by SBSE and GC–TOFMS with subsequent quantification for organochlorine–organophosphorus.. 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Molecular+Spectroscopy/Combining-Fast-Raman-Imaging-with-Optimization-of-/ArticleStandard/Article/detail/504355?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Atomic+Spectroscopy/RoHSWEEE-Application-of-a-Miniature-X-Ray-Spectrom/ArticleStandard/Article/detail/504352?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Atomic+Spectroscopy/Oil-Trace-Analysis-of-Sulfur-in-Fuels-Biofuels-and/ArticleStandard/Article/detail/504347?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Mass+Spectrometry+Forum+Column/Quantitative-Mass-Spectrometry-Part-III-An-Overvie/ArticleStandard/Article/detail/503644?ref=25 Columnist Ken Busch presents the third of a five-part series on quantitative mass spectrometry. In this installment, he focuses on an overview of regression analysis for calibration lines and curves in mass spectrometry. 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Market+Profile+Column/Market-Profile-UVVisNIR/ArticleStandard/Article/detail/503643?ref=25 While the overall laboratory UV and Visible spectroscopy market was worth well over $700 million in 2007, the UV/Vis/NIR segment represented less than 10% of it. UV/Vis/NIR instruments utilize multiple detectors to cover a broader spectrum of analysis, and typically are among the highest-end systems in the UV-Vis market. 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Molecular+Spectroscopy/High-Throughput-Push-Button-NMR-in-Fruit-Juice-Qua/ArticleStandard/Article/detail/504354?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Atomic+Spectroscopy/Direct-Analysis-of-Undiluted-Seawater-by-ICP-MS-Us/ArticleStandard/Article/detail/504351?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Molecular+Spectroscopy/Extending-the-Range-of-MCT-Focal-Plane-Arrays-Base/ArticleStandard/Article/detail/504358?ref=25 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/ICP-MS/Characterization-of-a-Complex-Protein-Mixture-Usin/ArticleStandard/Article/detail/505087?ref=25 The nanoLC LIT-TOF approach combines multiple capabilities that improve the ability to characterize complex protein mixtures significantly. 2008-03-01T05:00:00Z http://spectroscopymag.findpharma.com/spectroscopy/Application+Notes+-+Atomic+Spectroscopy/Analysis-of-Biodiesel-Utilizing-a-Simultaneous-CCD/ArticleStandard/Article/detail/504353?ref=25 2008-03-01T05:00:00Z